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A black Audi A4 is believed to have fled The Salisbury Club before police arrived on Sunday night.
Officers were called to the bar and venue, on Truro Avenue in Brinnington, around 10.45pm after reports of several injuries.
The car was later found abandoned in a middle lane of the M60, near to Redrock, with police suspecting the driver scaled a fence next to the motorway before running away.
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The clockwise stretch of the motorway between junction 25 and junction one was shut in the early hours of Monday.
A man, believed to be in his 30s, was taken to hospital where he died.
Police are continuing enquiries into the incident and their hunt for the driver.
Forensic officers were seen working behind a police cordon at the club on Monday.
On witness Sharon Mills, 44, told the Manchester Evening News: "They came out of the club fighting and a man got into his car and ran over a few people.
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"A man was on the floor with ambulance staff working on him, it was horrible."
Local councillor Chris Murphy said: "I am horrified this has happened. Brinnington is a decent place where the vast, vast majority of people are decent.
"But this gives it a bad name. If anyone knows anything about this then please come forward."
Greater Manchester Police detective inspector Kris Williams said: "My thoughts go out to the man's family who sadly have to deal with the tragic news that their loved one has died.
"We've already spoken to a number of witnesses in the area and will continue to do so to build a fuller picture of what has exactly happened but from what we know so far, we believe the driver of the car scaled the fence next to the M60 and ran away.
"Whatever information people have, I'd encourage them to contact us as a matter of urgency."
